Aging and disease

Atalayer D, Astbury NM.
PMID: 24124632
Aging Dis. 2013 Oct 01;4(5):264-75. doi: 10.14336/AD.2013.0400264.

We are expected to live longer than if we had been born 100 years ago however, the additional years are not necessarily spent in good health or free from disability. Body composition changes dramatically over the course of life....

Aging and disease

Cai M, Zhang W, Weng Z, Stetler RA, Jiang X, Shi Y, Gao Y, Chen J.
PMID: 28966799
Aging Dis. 2017 Oct 01;8(5):531-545. doi: 10.14336/AD.2017.0520. eCollection 2017 Oct.

The aged population is among the highest at risk for ischemic stroke, yet most stroke patients of advanced ages (>80 years) are excluded from access to thrombolytic treatment by tissue plasminogen activator, the only FDA approved pharmacological therapy for...

Aging and disease

Aunan JR, Cho WC, Søreide K.
PMID: 28966806
Aging Dis. 2017 Oct 01;8(5):628-642. doi: 10.14336/AD.2017.0103. eCollection 2017 Oct.

Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is increasing and the population in most...

Aging and disease

Giulia P, Michele L, Andrea F, Grazia D, Filomena C, Francesco P, Leandro C, Maria U, Carolina G, Massimiliano C, Antonio G.
PMID: 27493830
Aging Dis. 2015 Nov 24;7(4):318-25. doi: 10.14336/AD.2015.1124. eCollection 2016 Aug.

Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum suggesting that AD...

Aging and disease

Li J, Liu X, Zuo B, Zhang L.
PMID: 27493836
Aging Dis. 2015 Dec 06;7(4):514-25. doi: 10.14336/AD.2015.1206. eCollection 2016 Aug.

In the adult bone marrow, osteoblasts and adipocytes share a common precursor called mesenchymal stem cells (MSCs). The plasticity between the two lineages has been confirmed over the past decades, and has important implications in the etiology of bone...

Aging and disease

Gurses MS, Ural MN, Gulec MA, Akyol O, Akyol S.
PMID: 27493839
Aging Dis. 2016 Jan 11;7(4):479-90. doi: 10.14336/AD.2016.0111. eCollection 2016 Aug.

The extracellular matrix (ECM) is an environment that has various enzymes attended in regeneration and restoration processes which is very important to sustain physiological and biological functions of central nervous system (CNS). One of the participating enzyme systems in...

Aging and disease

Guzzardi MA, Iozzo P, Salonen MK, Kajantie E, Airaksinen R, Kiviranta H, Rantakokko P, Eriksson JG.
PMID: 27699078
Aging Dis. 2016 Oct 01;7(5):540-552. doi: 10.14336/AD.2016.0209. eCollection 2016 Oct.

As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since...

Aging and disease

Baumgaertel J, Haussmann R, Gruschwitz A, Werner A, Osterrath A, Lange J, Donix KL, Linn J, Donix M.
PMID: 27699079
Aging Dis. 2016 Oct 01;7(5):553-560. doi: 10.14336/AD.2016.0305. eCollection 2016 Oct.

Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure...

Aging and disease

Yan A, Cai G, Fu N, Feng Y, Sun J, Maimaiti Y, Zhou W, Fu Y.
PMID: 27699082
Aging Dis. 2016 Oct 01;7(5):593-603. doi: 10.14336/AD.2016.0201. eCollection 2016 Oct.

Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the...

Aging and disease

Qian L, Yuanshao L, Wensi H, Yulei Z, Xiaoli C, Brian W, Wanli Z, Zhengyi C, Jie X, Wenhui Z, Tieer Y, Hong W, Jincai H, Kunlin J, Bei S.
PMID: 27699084
Aging Dis. 2016 Oct 01;7(5):614-622. doi: 10.14336/AD.2016.0207. eCollection 2016 Oct.

Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed in various tissues and cells, and involved in pathogenesis of many human diseases. For example, IL-33 plays a protective role in cardiovascular diseases. However, the role of IL-33 in...

Aging and disease

Czick ME, Shapter CL, Silverman DI.
PMID: 27699086
Aging Dis. 2016 Oct 01;7(5):635-656. doi: 10.14336/AD.2016.0211. eCollection 2016 Oct.

Atrial fibrillation (AF) is the most prevalent arrhythmia in the world, due both to its tenacious treatment resistance, and to the tremendous number of risk factors that set the stage for the atria to fibrillate. Cardiopulmonary, behavioral, and psychological...

Frontiers in molecular neuroscience

Partearroyo T, Vallecillo N, Pajares MA, Varela-Moreiras G, Varela-Nieto I.
PMID: 28487633
Front Mol Neurosci. 2017 Apr 25;10:107. doi: 10.3389/fnmol.2017.00107. eCollection 2017.

Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells...